Table 5 Multivariate Cox regression analysis A) for HER2, B) for TOP2A and C) for both HER2 and TOP2A, adjusted for significant clinicopathological parameters in terms of DFS and OS

1.07

0.72-1.59

0.75

1.58

0.96-2.60

0.071

1.62

0.99-2.67

0.056

1.73

0.92-3.22

0.087

0.50

0.27-0.94

0.031

2.16

1.19-3.93

0.011

1.83

0.92-3.61

0.082

0.54

0.30-0.94

0.030

1.69

0.91-3.15

0.096

3.54

1.27-9.84

0.015

1.68

1.10-2.58

0.016

1.77

1.04-3.02

0.035

1.20

0.79-1.82

0.40

1.58

0.96-2.60

0.071

3.03

1.56-5.85

0.001

2.21

1.11-4.38

0.024

0.49

0.31-0.78

0.003

0.42

0.24-0.71

0.001

2.04

1.05-3.97

0.035

3.50

1.25-9.76

0.017

0.29

0.09-0.93

0.038

2.08

1.24-3.47

0.005

1.17

0.74-1.84

0.51

1.60

0.97-2.64

0.065

2.82

1.39-5.71

0.004

2.09

1.05-4.16

0.036

0.56

0.33-0.96

0.035

0.49

0.28-0.86

0.014

2.24

1.01-4.98

0.048

3.18

1.13-8.92

0.028

1.80

1.10-2.93

0.019

1.73

1.02-2.93

0.040

0.36

0.11-1.17

0.091

1.52

0.97-2.41

0.070

2.06

1.23-3.46

0.006