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Table 1 Arginase activity in EOC cell lines

From: rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

Cell line Ki67 (%) Arginase II RT-PCR Arginase activity (μg urea/mg protein) – control Arginase activity (μg urea/mg protein) – rIFN-γ-treated cells Cytostasis (%)
2774* 95 + 1.79 0.35 47.2 + 11.9
CAOV3 93 + 1.00 0.51 80.9 + 6.2
NMP-1 84 + 0.36 0.09 83.6 + 6.9
2008* 31 + 0.69 4.90 70.8 + 13.8
2008.C13 34 + 1.00 3.02 54.2 + 15.4
HEY 91 +/- 0.14 0.14 57.8 + 22.6
SKOV3 72 +/- 0.18 0.18 7.5 + 4.1
OVCAR3 54 +/- 0.08 0.09 44.1 + 19.1
  1. The percentage of Ki-67 was determined by immunocytochemistry, and the expression of arginase II was examined by RT-PCR as described in Materials and Methods. Arginase activity and growth inhibition were determined after 72 hours of incubation with control medium or rIFN-γ and are representative of 4 independent experiments. rIFN-γ was added daily to the cells. *Platinum-sensitive.