Figure 1From: rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibitionArginine pathway. L-arginine is metabolized either by nitric oxide synthase to N-hydroxy-L-arginine and NO, or by arginase to ornithine and urea. IFN-γ induces nitric oxide synthase, but inhibits arginase. N-hydroxy-L-arginine inhibits arginase, and NO inhibits ornithine decarboxylase.Back to article page