Figure 1

Cytotoxic responses by lymphocytes from HIV-seropositive donors. Results are shown of representative cytotoxicity assays (Cr⁵¹-release) using stimulated lymphocytes derived from three HLA-A2⁺, HIV-seropositive donors. Effector cells were mixed with T2 target cells presenting HLA-A2-restricted influenza A-derived FLU-M1:58–66 (■) or HIV-1-derived p17 GAG:77–85 (▲) peptide. T2 cells loaded with GP100:209–217 (●, Donors 1 and 2 only) or no peptide (◆) were used as controls as shown. Effector cells were tested after in vitro stimulation of PBMC with IL-2 and: no peptide (PBMC alone); FLU-M1:58–66; or GAG:77–85 peptide. Data points refer to percent lysis at indicated effector:target ratios.