Fig. 3

Histologic evidence for post-mi remote plaque activation. (A to D) Aortic root plaque histology from LDLR^−/−Apobec1^−/− mice at day 21 from each of the treatment groups including Masson’s trichrome (left panels) for plaque size and collagen, Mac2 staining (middle panels), and MMP9 (right panels) with DAPI counterstaining (blue) for nuclei. Scale bars = 100 μm for Masson’s and Mac 2; and 200 μm for MMP9. Quantitative histology data (mean ± SEM) are shown for (E) plaque area, (F) plaque area positive for Mac-2, (G) percent of plaque area positive for Mac-2, (H) plaque area positive for MMP9, (I) plaque collagen area, and (J) percent of plaque area positive for collagen. *p < 0.05, **p < 0.01 (by ANOVA corrected for multiple comparisons)