Changes in blood metabolomes as potential markers for severity and prognosis in doxorubicin-induced cardiotoxicity: a study in HER2-positive and HER2-negative breast cancer patients

Table 3 List of plasma metabolomes that were significantly altered (FDR < 0.05) only in HER2-positive or HER2-negative breast cancer patients at 2 weeks after completion of doxorubicin treatment

HER2-positive breast cancer patients (total 10 metabolomes)	HER2-negative breast cancer patients (total 6 metabolomes)
• Glycine	• Glutamine
• Isoleucine and leucine	• Tryptophan
• Phenylalanine	• Isovalerylcarnitine
• Malate	• Phosphatidylglycerol (34:1)
• Lysophosphatidylinositol (18:1)	• Phosphatidylglycerol (36:1)
• Phosphatidic acid (34:1)	• Phosphatidylglycerol (36:2)
• Phosphatidylcholine (36:1)
• Phosphatidylethanolamine (34:1)
• Phosphatidylethanolamine (38:4)
• Phosphatidylserine (40:6)

Data are summarized from Tables 1, 2. In fact, Table 1 represents 33 plasma metabolomes that were significantly altered (FDR < 0.05) at 2 weeks after completion of doxorubicin treatment in HER2-positive breast cancer patients, while Table 2 represents 29 plasma metabolomes that were significantly altered (FDR < 0.05) at 2 weeks after completion of doxorubicin treatment in HER2-negative breast cancer patients. According to Table 1, 10 of 33 plasma metabolomes were significantly altered only in HER2-positive breast cancer patients, whereas 23 of 33 plasma metabolomes were also significantly altered in HER2-negative breast cancer patients. According to Table 2, 6 of 29 plasma metabolomes were significantly altered only in HER2-negative breast cancer patients, whereas 23 of 29 plasma metabolomes were also significantly altered in HER2-positive breast cancer patients. Here in Table 3, we showed 10 of 33 plasma metabolomes that were significantly altered only in HER2-positive breast cancer patients and 6 of 29 plasma metabolomes that were significantly altered only in HER2-negative breast cancer patients
Bold: Significantly increased when compared to baseline
Italic: Significantly decreased when compared to baseline

ISSN: 1479-5876