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  1. The rapid emergence and global dissemination of the Omicron variant of SARS-CoV-2 have posed formidable challenges in public health. This scenario underscores the urgent need for an enhanced understanding of O...

    Authors: Qianyue Yang, Zhiwei Lin, Mingshan Xue, Yueting Jiang, Libing Chen, Jiahong Chen, Yuhong Liao, Jiali Lv, Baojun Guo, Peiyan Zheng, Huimin Huang and Baoqing Sun
    Citation: Journal of Translational Medicine 2024 22:219
  2. Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to...

    Authors: Xiangping Huang, Ling Wu, Qianhui Ouyang, Ying Huang, Lanhui Hong, Sixiang Liu, Kongzhi Yang, Ding Ning and Chao Chao Tan
    Citation: Journal of Translational Medicine 2024 22:218
  3. Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, but the early diagnosis rate is low. The RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in several cancers but its mec...

    Authors: Zelai He, Huijun Zhang, Haibo Xiao, Xiangyu Zhang, Hongbo Xu, Ruifen Sun and Siwen Li
    Citation: Journal of Translational Medicine 2024 22:216
  4. Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC, leading to poorer prognoses than those with PBC or AIH alone. The biom...

    Authors: Fan Yang, Leyu Zhou, Yi Shen, Xianglin Wang, Xiaoli Fan and Li Yang
    Citation: Journal of Translational Medicine 2024 22:214
  5. First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activ...

    Authors: Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon and Marcello Maugeri-Saccà
    Citation: Journal of Translational Medicine 2024 22:213
  6. Clear cell renal cell carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance of autophagy in ccRCC has been focused, and it has potential connect...

    Authors: Yu Huang, Zhiyong Xiong, Jianjun Wang, Yafen Gao, Qi Cao, Decai Wang, Jian Shi, Zhixian Chen and Xiong Yang
    Citation: Journal of Translational Medicine 2024 22:212
  7. Lactylation, a novel contributor to post-translational protein modifications, exhibits dysregulation across various tumors. Nevertheless, its intricate involvement in colorectal carcinoma, particularly for non...

    Authors: Huixia Huang, Keji Chen, Yifei Zhu, Zijuan Hu, Yaxian Wang, Jiayu Chen, Yuxue Li, Dawei Li and Ping Wei
    Citation: Journal of Translational Medicine 2024 22:211
  8. Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless...

    Authors: Guanwen Yang, Jiangting Cheng, Jiayi Xu, Chenyang Shen, Xuwei Lu, Chang He, Jiaqi Huang, Minke He, Jie Cheng and Hang Wang
    Citation: Journal of Translational Medicine 2024 22:210
  9. Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate in tumorigenesis and progression of various cancers. Our current research endeavore...

    Authors: Maojian Chen, Shaoping Zhang, Fan Wang, Junyi He, Wei Jiang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:209
  10. Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mi...

    Authors: Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande…
    Citation: Journal of Translational Medicine 2024 22:208
  11. The global cellular landscape of the tumor microenvironment (TME) combining primary and metastatic liver tumors has not been comprehensively characterized.

    Authors: Menghui Gui, Shilin Huang, Shizhou Li, Yuying Chen, Furong Cheng, Yulin Liu, Ji-ao Wang, Yuting Wang, Rui Guo, Yiming Lu, Pengbo Cao and Gangqiao Zhou
    Citation: Journal of Translational Medicine 2024 22:206
  12. Flavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dieta...

    Authors: Runmiao Wu, Xu Zhu, Gongchang Guan, Qianwei Cui, Ling Zhu, Yujie Xing and Jingsha Zhao
    Citation: Journal of Translational Medicine 2024 22:205
  13. Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown.

    Authors: Abhishek Singh Sengar, Manish Kumar, Chetna Rai, Sreemoyee Chakraborti, Dinesh Kumar, Pranesh Kumar, Sukhes Mukherjee, Kausik Mondal, Adele Stewart and Biswanath Maity
    Citation: Journal of Translational Medicine 2024 22:204
  14. Resident memory T (Trm) cells which are specifically located in non-lymphoid tissues showed distinct phenotypes and functions compared to circulating memory T cells and were vital for the initiation of robust ...

    Authors: Jialing Fang, Jun Lei, Boxiao He, Yankang Wu, Peng Chen, Zaiqiao Sun, Ning Wu, Yafei Huang, Pengcheng Wei, Lei Yin and Yongshun Chen
    Citation: Journal of Translational Medicine 2024 22:203
  15. Although the long-term prognosis of papillary thyroid cancer (PTC) is favorable, distant metastasis significantly compromises the prognosis and quality of life for patients with PTC. The Cadherin family plays ...

    Authors: Luyao Wu, Jian Xiao, Dandan Yi, Haoran Ding, Ru Wang, Zehua Duan, Zhijian Liu, Xianbiao Shi, Meiping Shen and Jianfeng Sang
    Citation: Journal of Translational Medicine 2024 22:201
  16. Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has co...

    Authors: Cláudia Febra, Joana Saraiva, Fátima Vaz, João Macedo, Hamza Mohammad Al-Hroub, Mohammad Harb Semreen, Rui Maio, Vitor Gil, Nelson Soares and Deborah Penque
    Citation: Journal of Translational Medicine 2024 22:200
  17. Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not ...

    Authors: Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang and Tao Li
    Citation: Journal of Translational Medicine 2024 22:199
  18. Angiogenesis inhibitors have been identified to improve the efficacy of immunotherapy in recent studies. However, the delayed therapeutic effect of immunotherapy poses challenges in treatment planning. Therefo...

    Authors: Xi Xu, Mengjie Ma, Kunlin Ye, Dong Zhang, Xinhui Chen, Jiayang Wu, Xukai Mo, Zeyu Xiao, Changzheng Shi and Liangping Luo
    Citation: Journal of Translational Medicine 2024 22:198
  19. Metabolic and bariatric surgery (MBS) is safe and efficacious in treating adolescents with severe obesity. Behavioral/lifestyle programs can support successful preparation for surgery and post-MBS weight loss,...

    Authors: Maral Misserian, Alicia Wheelington, Rashon King, Jackson Francis, M. Sunil Mathew, Marlyn A. Allicock, Bethany R. Cartwright, Adejumoke Adewunmi, Aparajita Chandrasekhar, Dhatri Polavarapu, Faisal G. Qureshi, Sarah E. Barlow and Sarah E. Messiah
    Citation: Journal of Translational Medicine 2024 22:197
  20. Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatt...

    Authors: Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao and Na Sun
    Citation: Journal of Translational Medicine 2024 22:196
  21. Immunotherapy has significantly improved survival of esophageal squamous cell cancer (ESCC) patients, however the clinical benefit was limited to only a small portion of patients. This study aimed to perform a...

    Authors: Butuo Li, Wenru Qin, Linlin Yang, Haoqian Li, Chao Jiang, Yueyuan Yao, Shuping Cheng, Bing Zou, Bingjie Fan, Taotao Dong and Linlin Wang
    Citation: Journal of Translational Medicine 2024 22:195
  22. Peripheral nerve injury (PNI) is commonly observed in clinical practice, yet the underlying mechanisms remain unclear. This study investigated the correlation between the expression of a Ras-related protein Ra...

    Authors: Jiayi Wang, Pin Chen, Guanjie Han, Yongjie Zhou, Xingdong Xiang, Mengxuan Bian, Lei Huang, Xiang Wang, Binfeng He and Shunyi Lu
    Citation: Journal of Translational Medicine 2024 22:194
  23. Aberrant upregulation of the ubiquitin-specific protease 14 (USP14) has been found in some malignant tumors, including oral squamous cell carcinoma (OSCC). In this study, we further demonstrated that aberrantl...

    Authors: Xingming Zhang, Lou Geng, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu and Wenli Gu
    Citation: Journal of Translational Medicine 2024 22:193
  24. Zinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer (EOC) remains unknown. In this study, we aimed to investigate the clin...

    Authors: Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao and Kun Shi
    Citation: Journal of Translational Medicine 2024 22:192
  25. In the Netherlands, the prevalence of post COVID-19 condition is estimated at 12.7% at 90–150 days after SARS-CoV-2 infection. This study aimed to determine the occurrence of fatigue and other symptoms, to ass...

    Authors: Merel E. B. Cornelissen, Lizan D. Bloemsma, Anouk W. Vaes, Nadia Baalbaki, Qichen Deng, Rosanne J. H. C. G. Beijers, Lieke C. E. Noij, Laura Houweling, Somayeh Bazdar, Martijn A. Spruit and Anke H. Maitland-van der Zee
    Citation: Journal of Translational Medicine 2024 22:191
  26. Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti–PD-1 Response Prediction DREAM Chal...

    Authors: Mike Mason, Óscar Lapuente-Santana, Anni S. Halkola, Wenyu Wang, Raghvendra Mall, Xu Xiao, Jacob Kaufman, Jingxin Fu, Jacob Pfeil, Jineta Banerjee, Verena Chung, Han Chang, Scott D. Chasalow, Hung Ying Lin, Rongrong Chai, Thomas Yu…
    Citation: Journal of Translational Medicine 2024 22:190
  27. Combined small-cell lung carcinoma (cSCLC) represents a rare subtype of SCLC, the mechanisms governing the evolution of cancer genomes and their impact on the tumor immune microenvironment (TIME) within distin...

    Authors: Wenjuan Ma, Ting Zhou, Mengmeng Song, Jiaqing Liu, Gang Chen, Jianhua Zhan, Liyan Ji, Fan Luo, Xuan Gao, Pansong Li, Xuefeng Xia, Yan Huang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:189
  28. Diagnosis of colorectal cancer (CRC) during early stages can greatly improve patient outcome. Although technical advances in the field of genomics and proteomics have identified a number of candidate biomarker...

    Authors: Hanju Hua, Tingting Wang, Liangxuan Pan, Xiaoyao Du, Tianxue Xia, Zhenzhong Fa, Lei Gu, Fei Gao, Chaohui Yu, Feng Gao, Lujian Liao and Zhe Shen
    Citation: Journal of Translational Medicine 2024 22:188
  29. The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific immune response of the transplanted cells within the ta...

    Authors: Moritz Schweins, Ralf Gäbel, Matti Raitza, Praveen Vasudevan, Heiko Lemcke, Markus Joksch, Anna Schildt, Jens Kurth, Tobias Lindner, Felix G. Meinel, Alper Öner, Hüseyin Ince, Brigitte Vollmar, Bernd Joachim Krause, Robert David and Cajetan Immanuel Lang
    Citation: Journal of Translational Medicine 2024 22:187
  30. Kidney transplantation stands out as the most effective renal replacement therapy for patients grappling with end-stage renal disease. However, post-transplant renal fibrosis is a prevalent and irreversible co...

    Authors: Xinhao Niu, Cuidi Xu, Yin Celeste Cheuk, Xiaoqing Xu, Lifei Liang, Pingbao Zhang and Ruiming Rong
    Citation: Journal of Translational Medicine 2024 22:186
  31. Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world data and experimental comparison data for tasks such as ris...

    Authors: Huimin Qiao, Yijing Chen, Changshun Qian and You Guo
    Citation: Journal of Translational Medicine 2024 22:185
  32. We previously showed that the nab-paclitaxel plus S-1 (NPS) regimen had promising effects against metastatic pancreatic ducal adenocarcinoma (mPDAC), whose efficacy however could not be precisely predicted by ...

    Authors: Lei Huang, Yao Lv, Shasha Guan, Huan Yan, Lu Han, Zhikuan Wang, Quanli Han, Guanghai Dai and Yan Shi
    Citation: Journal of Translational Medicine 2024 22:184
  33. Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtyp...

    Authors: Yong Peng, Huan Yang, Quan Chen, Hong Jin, Ya-hui Xue, Miao-qiao Du, Shu Liu and Shun-yu Yao
    Citation: Journal of Translational Medicine 2024 22:183
  34. Digital histopathology provides valuable information for clinical decision-making. We hypothesized that a deep risk network (DeepRisk) based on digital pathology signature (DPS) derived from whole-slide images...

    Authors: Mengxin Tian, Zhao Yao, Yufu Zhou, Qiangjun Gan, Leihao Wang, Hongwei Lu, Siyuan Wang, Peng Zhou, Zhiqiang Dai, Sijia Zhang, Yihong Sun, Zhaoqing Tang, Jinhua Yu and Xuefei Wang
    Citation: Journal of Translational Medicine 2024 22:182
  35. The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactur...

    Authors: David F. Stroncek, Nan Zhang, Jiaqiang Ren, Rob Somerville and Anh Dinh
    Citation: Journal of Translational Medicine 2024 22:181
  36. The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and infant health. The exact mechanism underlying changes in plasma f...

    Authors: Haoyi Du, Danyang Li, Laura Monjowa Molive and Na Wu
    Citation: Journal of Translational Medicine 2024 22:180
  37. Acute pancreatitis and non-alcoholic fatty liver disease are both serious diseases in the digestive system. The pathogenesis of both diseases is extremely complex closely and it related to gut microbiota, infl...

    Authors: Congzhi Yan, Jingxia Bao and Jinji Jin
    Citation: Journal of Translational Medicine 2024 22:179
  38. Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated. This study aimed to clarify the role and mechanism of Human antigen R...

    Authors: Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li and Gang Huang
    Citation: Journal of Translational Medicine 2024 22:178
  39. Human health is seriously threatened by antibiotic-induced intestinal disorders. Herein, we aimed to determine the effects of Autoinducer-2 (AI-2) combined with Lactobacillus rhamnosus GG (LGG) on the intestinal ...

    Authors: Riqiang Hu, Ting Yang, Qing Ai, Yuan Shi, Yanchun Ji, Qian Sun, Bei Tong, Jie Chen and Zhengli Wang
    Citation: Journal of Translational Medicine 2024 22:177
  40. The need for radiotherapy among the elderly rises with increasing life expectancy and a corresponding increase of elderly cancer patients. Radiation-induced skin injury is one of the most frequent adverse effe...

    Authors: Yan Chen, Le Ma, Zhuo Cheng, Zhihe Hu, Yang Xu, Jie Wu, Yali Dai and Chunmeng Shi
    Citation: Journal of Translational Medicine 2024 22:176
  41. Colorectal cancer (CRC) is the leading cancer worldwide. Microbial agents have been considered to contribute to the pathogenesis of different disease. But the underlying relevance between CRC and microbiota re...

    Authors: Shaomin Zou, Chao Yang, Jieping Zhang, Dan Zhong, Manqi Meng, Lu Zhang, Honglei Chen and Lekun Fang
    Citation: Journal of Translational Medicine 2024 22:175
  42. Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, t...

    Authors: Qiqi Zhu, Yiming Yang, Kexin Chen, Qiaoyu Zhang, Yifan Huang and Shunhai Jian
    Citation: Journal of Translational Medicine 2024 22:174
  43. Lung cancer, a prevalent and aggressive disease, is characterized by recurrence and drug resistance. It is essential to comprehend the fundamental processes and discover novel therapeutic objectives for augmen...

    Authors: Ailing Wang, Wei-sha Zheng, Zhen Luo, Lian Bai and Shi Zhang
    Citation: Journal of Translational Medicine 2024 22:173
  44. The global incidence of Chronic Kidney Disease (CKD) is steadily escalating, with discernible linkage to the intricate terrain of intestinal microecology. The intestinal microbiota orchestrates a dynamic equil...

    Authors: Meng He, Wenqian Wei, Yichen Zhang, Zhouxia Xiang, Dan Peng, Ayijiaken Kasimumali and Shu Rong
    Citation: Journal of Translational Medicine 2024 22:172
  45. Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in hematological malignancies with several approved products, but not in solid tumors. Patients suffer from limited response and tu...

    Authors: Jianbin Ye, Qiaoyuan Liu, Yunxuan He, Zhenkun Song, Bao Lin, Zhiwei Hu, Juanyuan Hu, Yunshan Ning, Cheguo Cai and Yan Li
    Citation: Journal of Translational Medicine 2024 22:171
  46. Hepatocellular carcinoma (HCC) is characterized by aggressive progression and elevated mortality rates. This study aimed to investigate the regulatory effects of RBBP7 on HCC pathogenesis and the underlying me...

    Authors: Yuan Fang, WeiQiang Tang, Siming Qu, ZhiTao Li, XiaoLi Zhang, YingLei Miao, Zhong Zeng and HanFei Huang
    Citation: Journal of Translational Medicine 2024 22:170
  47. Adenomatous polyps (APs) with inflammation are risk factors for colorectal cancer. However, the role of inflammation-related gut microbiota in promoting the progression of APs is unknown.

    Authors: Shoujuan Yu, Xifan Wang, Ziyang Li, Dekui Jin, Mengyang Yu, Jingnan Li, Yixuan Li, Xiaoxue Liu, Qi Zhang, Yinghua Liu, Rong Liu, Xiaoyu Wang, Bing Fang, Chengying Zhang, Ran Wang and Fazheng Ren
    Citation: Journal of Translational Medicine 2024 22:169
  48. MicroRNA (miRNA)-based therapies have shown great potential in myocardial repair following myocardial infarction (MI). MicroRNA-302 (miR302) has been reported to exert a protective effect on MI. However, miRNA...

    Authors: Jianjun Gu, Jia You, Hao Liang, Jiacai Zhan, Xiang Gu and Ye Zhu
    Citation: Journal of Translational Medicine 2024 22:168

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