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  1. Research

    Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation

    Low to moderate inorganic arsenic (iAs) exposure is independently associated with cardiovascular disease (CVD), particularly for patients with diabetes mellitus (DM). The mechanism of increased CVD risk from i...

    Jonathan D. Newman, Christina T. Echagarruga, Yoscar M. Ogando, Emilie Montenont, Yu Chen, Edward A. Fisher and Jeffrey S. Berger

    Journal of Translational Medicine 2017 15:55

    Published on: 6 March 2017

  2. Research

    Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts

    Endothelial and smooth muscle cells are considered promising resources for regenerative medicine and cell replacement therapy. It has been shown that both types of cells are heterogeneous depending on the type...

    I. S. Zakharova, M. K. Zhiven’, Sh. B. Saaya, A. I. Shevchenko, A. M. Smirnova, A. Strunov, A. A. Karpenko, E. A. Pokushalov, L. N. Ivanova, P. I. Makarevich, Y. V. Parfyonova, E. Aboian and S. M. Zakian

    Journal of Translational Medicine 2017 15:54

    Published on: 3 March 2017

  3. Research

    Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies

    Although discovery research has identified the importance of dozens of pro- and anti-inflammatory immune mediators in the pathogenesis, maintenance, exacerbation and resolution of inflammatory diseases, most h...

    C. Graham, R. Chooniedass, W. P. Stefura, L. Lotoski, P. Lopez, A. D. Befus, A. B. Becker and K. T. HayGlass

    Journal of Translational Medicine 2017 15:53

    Published on: 2 March 2017

  4. Erratum

    Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

    Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh and Charlotte A. Peterson

    Journal of Translational Medicine 2017 15:45

    Published on: 28 February 2017

    The original article was published in Journal of Translational Medicine 2016 14:284

  5. Research

    Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway

    Gastric cancer (GC) is one of the most malignant tumors and the second leading cause of cancer-related deaths in the world. Luteolin, a flavonoid present in many fruits and green plants, suppresses cancer prog...

    Ming-de Zang, Lei Hu, Zhi-yuan Fan, He-xiao Wang, Zheng-lun Zhu, Shu Cao, Xiong-yan Wu, Jian-fang Li, Li-ping Su, Chen Li, Zheng-gang Zhu, Min Yan and Bing-ya Liu

    Journal of Translational Medicine 2017 15:52

    Published on: 27 February 2017

  6. Review

    Heterogeneity of Toll-like receptor 9 signaling in B cell malignancies and its potential therapeutic application

    Toll-like receptor 9 (TLR9) is expressed in a variety of B-cell malignancies and works as a bridge between innate and adaptive immunity. CpG oligodeoxynucleotides (CpG ODNs), TLR9 agonists, are able to induce ...

    Ling Bai, Wei Chen, Jingtao Chen, Wei Li, Lei Zhou, Chao Niu, Wei Han and Jiuwei Cui

    Journal of Translational Medicine 2017 15:51

    Published on: 27 February 2017

  7. Research

    A rabbit model for experimental alveolar cleft grafting

    The purpose of the present study was to develop an animal model for creating alveolar cleft defects with properly simulated clinical defect environment for tissue-engineered bone-substitute materials testing w...

    Mohammad Kamal, Lars Andersson, Rene Tolba, Alexander Bartella, Felix Gremse, Frank Hölzle, Peter Kessler and Bernd Lethaus

    Journal of Translational Medicine 2017 15:50

    Published on: 24 February 2017

  8. Review

    Therapeutic strategies for cell-based neovascularization in critical limb ischemia

    Critical limb ischemia (CLI) causes severe ischemic rest pain, ulcer, and gangrene in the lower limbs. In spite of angioplasty and surgery, CLI patients without suitable artery inflow or enough vascular bed in...

    Makoto Samura, Tohru Hosoyama, Yuriko Takeuchi, Koji Ueno, Noriyasu Morikage and Kimikazu Hamano

    Journal of Translational Medicine 2017 15:49

    Published on: 24 February 2017

  9. Research

    Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy

    Bone marrow mesenchymal stem cells (BMMSCs) and bone marrow mononuclear cells (BMMNCs) are both used to treat spastic cerebral palsy. However, the differences in therapeutic effect remain unknown.

    Xuebin Liu, Xiaojun Fu, Guanghui Dai, Xiaodong Wang, Zan Zhang, Hongbin Cheng, Pei Zheng and Yihua An

    Journal of Translational Medicine 2017 15:48

    Published on: 24 February 2017

  10. Research

    Circulating tumor cells capture disease evolution in advanced prostate cancer

    Genetic analysis of advanced cancer is limited by availability of representative tissue. Biopsies of prostate cancer metastasized to bone are invasive with low quantity of tumor tissue. The prostate cancer gen...

    Justin Lack, Marc Gillard, Maggie Cam, Gladell P. Paner and David J. VanderWeele

    Journal of Translational Medicine 2017 15:44

    Published on: 23 February 2017

  11. Research

    Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

    Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4...

    Mikhail Burmakin, Tijs van Wieringen, P. Olof Olsson, Linda Stuhr, Aive Åhgren, Carl-Henrik Heldin, Rolf K. Reed, Kristofer Rubin and Carina Hellberg

    Journal of Translational Medicine 2017 15:47

    Published on: 23 February 2017

  12. Research

    COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

    The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have prompted investigators to implement novel clinical trials which combine immunotherapy with different treatment modalities. Moreover is...

    Gerardo Botti, Federica Fratangelo, Margherita Cerrone, Giuseppina Liguori, Monica Cantile, Anna Maria Anniciello, Stefania Scala, Crescenzo D’Alterio, Chiara Trimarco, Angela Ianaro, Giuseppe Cirino, Corrado Caracò, Maria Colombino, Giuseppe Palmieri, Stefano Pepe, Paolo Antonio Ascierto…

    Journal of Translational Medicine 2017 15:46

    Published on: 23 February 2017

  13. Meeting abstracts

    Proceedings of the 4th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2016

    Lauren E. Cornell, Whitney Greene, Rachel O. Haich, Lee C. Mangum, Gerardo R. Garcia, Charles H. Guymon, Kevin S. Akers, Jennifer Landry, Jennifer McDaniel, Gina Griffith, Elaine Por, David Rios, David Zamora, Brian Lund, Alexandra M. Forbes, Joel D. Newton…

    Journal of Translational Medicine 2017 15(Suppl 2):19

    Published on: 22 February 2017

    This article is part of a Supplement: Volume 15 Supplement 2

  14. Research

    TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents

    Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignan...

    Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado and Raffaele D’Amelio

    Journal of Translational Medicine 2017 15:38

    Published on: 21 February 2017

  15. Research

    Melanoma antigen-specific effector T cell cytokine secretion patterns in patients treated with ipilimumab

    In a previously reported study, patients with regionally advanced melanoma were treated with neoadjuvant ipilimumab (ipi) (Tarhini in PLoS ONE 9(2): e87705, 3). Significant changes in circulating myeloid derived...

    Yana G. Najjar, Fei Ding, Yan Lin, Robert VanderWeele, Lisa H. Butterfield and Ahmad A. Tarhini

    Journal of Translational Medicine 2017 15:39

    Published on: 21 February 2017

  16. Methodology

    Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

    Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety and feasibility of a T regulatory type 1 (Tr1)-ce...

    Bechara Mfarrej, Eleonora Tresoldi, Angela Stabilini, Alessia Paganelli, Rossana Caldara, Antonio Secchi and Manuela Battaglia

    Journal of Translational Medicine 2017 15:40

    Published on: 21 February 2017

  17. Research

    Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study

    Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specif...

    Isabel De Castro-Orós, Pilar Irún, Jorge Javier Cebolla, Victor Rodriguez-Sureda, Miguel Mallén, María Jesús Pueyo, Pilar Mozas, Carmen Dominguez and Miguel Pocoví

    Journal of Translational Medicine 2017 15:43

    Published on: 21 February 2017

  18. Research

    Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing

    Diminished wound healing is a major complication of diabetes mellitus and can lead to foot ulcers. However, there are limited therapeutic methods to treat this condition. Exendin-4 (Ex-4), a glucagon-like pept...

    Eunhui Seo, Jae Soo Lim, Jin-Bum Jun, Woohyuk Choi, In-Sun Hong and Hee-Sook Jun

    Journal of Translational Medicine 2017 15:35

    Published on: 15 February 2017

  19. Research

    Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia

    Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myost...

    Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno and Umberto Tarantino

    Journal of Translational Medicine 2017 15:34

    Published on: 15 February 2017

  20. Review

    Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

    Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known re...

    Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo and Marta Chagas Monteiro

    Journal of Translational Medicine 2017 15:36

    Published on: 15 February 2017

  21. Research

    A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway

    Mesenchymal stem cell (MSC) has been widely explored in the past decade as a cell-based treatment for various diseases. However, poor survival of adaptively transferred MSCs limits their clinical therapeutic p...

    Shuo Wang, Chao Zhang, Sidikejiang Niyazi, Long Zheng, Jiawei Li, Weitao Zhang, Ming Xu, Ruiming Rong, Cheng Yang and Tongyu Zhu

    Journal of Translational Medicine 2017 15:33

    Published on: 15 February 2017

  22. Research

    Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

    Macrophages (Mφs) constitute a major component of the leukocyte infiltrate and perform distinct roles in different tumor microenvironments. This study aimed to characterize the distribution, composition and pr...

    Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-jing Fang and Jing Xu

    Journal of Translational Medicine 2017 15:37

    Published on: 15 February 2017

  23. Research

    Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group

    The shift towards an earlier diagnosis of breast cancer (BC) highlights the need for biomarkers that would identify patients at risk for relapse and metastatic spread and indicate the potential value of additi...

    Amanda Psyrri, Konstantine T. Kalogeras, Ralph M. Wirtz, George Kouvatseas, Georgia Karayannopoulou, Anna Goussia, Flora Zagouri, Elke Veltrup, Eleni Timotheadou, Helen Gogas, Angelos Koutras, Georgios Lazaridis, Christos Christodoulou, George Pentheroudakis, Panagiota Economopoulou, Apostolos Laskarakis…

    Journal of Translational Medicine 2017 15:30

    Published on: 13 February 2017

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