Volume 12 Supplement 2

Systems medicine in chronic diseases: COPD as a use case

Research

Edited by David Gomez Cabrero, Felip Miralles, Jesper Tegner, Josep Roca, Magi Lluch-Ariet and Marta Cascante

Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication chanrges can be found in the individual articles. Articles have undergone the journal's standard peer review process for supplements. The Supplement Editors declare that they have no competing interests.

  1. Introduction

    Synergy-COPD: a systems approach for understanding and managing chronic diseases

    Chronic diseases (CD) are generating a dramatic societal burden worldwide that is expected to persist over the next decades. The challenges posed by the epidemics of CD have triggered a novel health paradigm w...

    David Gomez-Cabrero, Magi Lluch-Ariet, Jesper Tegnér, Marta Cascante, Felip Miralles and Josep Roca

    Journal of Translational Medicine 2014 12(Suppl 2):S2

    Published on: 28 November 2014

  2. Review

    Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management

    Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and management. Implicit...

    Josep Roca, Claudia Vargas, Isaac Cano, Vitaly Selivanov, Esther Barreiro, Dieter Maier, Francesco Falciani, Peter Wagner, Marta Cascante, Judith Garcia-Aymerich, Susana Kalko, Igor Marin De Mas, Jesper Tegnér, Joan Escarrabill, Alvar Agustí and David Gomez-Cabrero

    Journal of Translational Medicine 2014 12(Suppl 2):S3

    Published on: 28 November 2014

  3. Research

    Systems Medicine: from molecular features and models to the clinic in COPD

    Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes a...

    David Gomez-Cabrero, Jörg Menche, Isaac Cano, Imad Abugessaisa, Mercedes Huertas-Migueláñez, Akos Tenyi, Igor Marin de Mas, Narsis A Kiani, Francesco Marabita, Francesco Falciani, Kelly Burrowes, Dieter Maier, Peter Wagner, Vitaly Selivanov, Marta Cascante, Josep Roca…

    Journal of Translational Medicine 2014 12(Suppl 2):S4

    Published on: 28 November 2014

  4. Research

    Computational modeling of the obstructive lung diseases asthma and COPD

    Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway obstruction and airflow limitation and pose a huge burden to society. These obstructive lung diseases impact the lung physiol...

    Kelly Suzanne Burrowes, Tom Doel and Chris Brightling

    Journal of Translational Medicine 2014 12(Suppl 2):S5

    Published on: 28 November 2014

  5. Research

    The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research

    Previously we generated a chronic obstructive pulmonary disease (COPD) specific knowledge base (http://​www.​copdknowledgebas​e.​eu) from clinical and expe...

    Isaac Cano, Ákos Tényi, Christine Schueller, Martin Wolff, M Mercedes Huertas Migueláñez, David Gomez-Cabrero, Philipp Antczak, Josep Roca, Marta Cascante, Francesco Falciani and Dieter Maier

    Journal of Translational Medicine 2014 12(Suppl 2):S6

    Published on: 28 November 2014

  6. Research

    Simulation environment and graphical visualization environment: a COPD use-case

    Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which ...

    Mercedes Huertas-Migueláñez, Daniel Mora, Isaac Cano, Dieter Maier, David Gomez-Cabrero, Magí Lluch-Ariet and Felip Miralles

    Journal of Translational Medicine 2014 12(Suppl 2):S7

    Published on: 28 November 2014

  7. Research

    Knowledge sharing in the health scenario

    The understanding of certain data often requires the collection of similar data from different places to be analysed and interpreted. Interoperability standards and ontologies, are facilitating data interchang...

    Magí Lluch-Ariet, Albert Brugués de la Torre, Francesc Vallverdú and Josep Pegueroles-Vallés

    Journal of Translational Medicine 2014 12(Suppl 2):S8

    Published on: 28 November 2014

  8. Research

    Clinical Decision Support Systems (CDSS) for preventive management of COPD patients

    The use of information and communication technologies to manage chronic diseases allows the application of integrated care pathways, and the optimization and standardization of care processes. Decision support...

    Filip Velickovski, Luigi Ceccaroni, Josep Roca, Felip Burgos, Juan B Galdiz, Nuria Marina and Magí Lluch-Ariet

    Journal of Translational Medicine 2014 12(Suppl 2):S9

    Published on: 28 November 2014

  9. Review

    Workforce preparation: the Biohealth computing model for Master and PhD students

    The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiative...

    Marta Cascante, Pedro de Atauri, David Gomez-Cabrero, Peter Wagner, Josep Joan Centelles, Silvia Marin, Isaac Cano, Filip Velickovski, Igor Marin de Mas, Dieter Maier, Josep Roca and Philippe Sabatier

    Journal of Translational Medicine 2014 12(Suppl 2):S11

    Published on: 28 November 2014

  10. Review

    Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project

    Chronic Obstructive Pulmonary Disease (COPD) is a major challenge for healthcare. Heterogeneities in clinical manifestations and in disease progression are relevant traits in COPD with impact on patient manage...

    Felip Miralles, David Gomez-Cabrero, Magí Lluch-Ariet, Jesper Tegnér, Marta Cascante and Josep Roca

    Journal of Translational Medicine 2014 12(Suppl 2):S12

    Published on: 28 November 2014

  11. Research

    Biomedical research in a Digital Health Framework

    This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements -...

    Isaac Cano, Magí Lluch-Ariet, David Gomez-Cabrero, Dieter Maier, Susana Kalko, Marta Cascante, Jesper Tegnér, Felip Miralles, Diego Herrera and Josep Roca

    Journal of Translational Medicine 2014 12(Suppl 2):S10

    Published on: 28 November 2014