Personalized medicine

Section edited by Lotfi Chouchane

This section aims to provide a platform for research that will revolutionize patient care through the use of novel molecular predisposing screening, diagnostic, prognostic and pharmacogenomics. Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine will impact the way that medicine is practiced.

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  1. Research

    A multi-site feasibility study for personalized medicine in canines with Osteosarcoma

    A successful therapeutic strategy, specifically tailored to the molecular constitution of an individual and their disease, is an ambitious objective of modern medicine. In this report, we highlight a feasibili...

    Noel R Monks, David M Cherba, Steven G Kamerling, Heather Simpson, Anthony W Rusk, Derrick Carter, Emily Eugster, Marie Mooney, Robert Sigler, Matthew Steensma, Tessa Grabinski, Keith R Marotti and Craig P Webb

    Journal of Translational Medicine 2013 11:158

    Published on: 1 July 2013

  2. Research

    Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians

    Large databases focused on genetic susceptibility to prostate cancer have been accumulated from population studies of different ancestries, including Europeans and African-Americans. Arab populations, however,...

    Jingxuan Shan, Khalid Al-Rumaihi, Danny Rabah, Issam Al-Bozom, Dhanya Kizhakayil, Karim Farhat, Sami Al-Said, Hala Kfoury, Shoba P Dsouza, Jillian Rowe, Hanif G Khalak, Shahzad Jafri, Idil I Aigha and Lotfi Chouchane

    Journal of Translational Medicine 2013 11:121

    Published on: 13 May 2013

  3. Research

    High EGFR copy number predicts benefits from tyrosine kinase inhibitor treatment for non-small cell lung cancer patients with wild-type EGFR

    This study was designed to determine whether advanced non-small-cell lung cancer (NSCLC) patients with high copy number of epidermal growth factor receptor (EGFR) can benefit from treatment with EGFR-tyrosine ...

    Fang Wang, Sha Fu, Qiong Shao, Yan-Bin Zhou, Xiao Zhang, Xu Zhang, Cong Xue, Jian-Guang Lin, Li-Xia Huang, Li Zhang, Wei-Min Zhang and Jian-Yong Shao

    Journal of Translational Medicine 2013 11:90

    Published on: 4 April 2013

  4. Research

    Prothrombotic gene variants as risk factors of acute myocardial infarction in young women

    Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factor...

    Rossella Tomaiuolo, Chiara Bellia, Antonietta Caruso, Rosanna Di Fiore, Sandro Quaranta, Davide Noto, Angelo B Cefalù, Pierpaolo Di Micco, Federica Zarrilli, Giuseppe Castaldo, Maurizio R Averna and Marcello Ciaccio

    Journal of Translational Medicine 2012 10:235

    Published on: 21 November 2012

  5. Research

    Identification of SLC26A4 c.919-2A>G compound heterozygosity in hearing-impaired patients to improve genetic counseling

    Mutations in the SLC26A4 gene, which encodes the anion transporter, pendrin, are a major cause of autosomal recessive non-syndromic hearing loss (NSHL) in some Asian populations. SLC26A4 c.919-2A>G (IVS7-2A>G)...

    Qi Li, Qing-wen Zhu, Yong-yi Yuan, Sha-sha Huang, Dong-yi Han, De-liang Huang and Pu Dai

    Journal of Translational Medicine 2012 10:225

    Published on: 14 November 2012

  6. Research

    A gender-related action of IFNbeta-therapy was found in multiple sclerosis

    Understanding how sexual dimorphism affects the physiological and pathological responses of the immune system is of considerable clinical importance and could lead to new approaches in therapy. Sexual dimorphi...

    Ida Contasta, Rocco Totaro, Patrizia Pellegrini, Tiziana Del Beato, Antonio Carolei and Anna Maria Berghella

    Journal of Translational Medicine 2012 10:223

    Published on: 14 November 2012

  7. Review

    Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: How markers of β-cell loss may assist

    Disease heterogeneity is as major issue in Type II Diabetes Mellitus (T2DM), and this patient inter-variability might not be sufficiently reflected by measurements of glycated haemoglobin (HbA1c).

    Anita V Neutzsky-Wulff, Kim V Andreassen, Sara T Hjuler, Michael Feigh, Anne-Christine Bay-Jensen, Qinlong Zheng, Kim Henriksen and Morten A Karsdal

    Journal of Translational Medicine 2012 10:214

    Published on: 30 October 2012

  8. Research

    Five novel glucose-6-phosphate dehydrogenase deficiency haplotypes correlating with disease severity

    Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) deficiency is caused by one or more mutations in the G6PD gene on chromosome X. An association between enzyme levels and gene haplotypes remains to be establi...

    Ashraf Dallol, Huda Banni, Mamdooh A Gari, Mohammed H Al-Qahtani, Adel M Abuzenadeh, Fatin Al-Sayes, Adeel G Chaudhary, Jeffrey Bidwell and Wael Kafienah

    Journal of Translational Medicine 2012 10:199

    Published on: 24 September 2012

  9. Research

    Preoperative Cyfra21-1 and SCC-Ag serum titers predict survival in patients with stage II esophageal squamous cell carcinoma

    The purpose of this study is to evaluate the predictive significance of preoperative serum level of cytokeratin 19 fragments (Cyfra21-1) and squamous cell carcinoma antigen (SCC-Ag) after complete resection in...

    Xun Cao, Lin Zhang, Gui-Rong Feng, Juan Yang, Ruo-Yan Wang, Jun Li, Xiao-Min Zheng and Yu-Jing Han

    Journal of Translational Medicine 2012 10:197

    Published on: 21 September 2012

  10. Research

    Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients

    The clinical course of cutaneous melanoma (CM) can differ significantly for patients with identical stages of disease, defined clinico-pathologically, and no molecular markers differentiate patients with such ...

    Luca Sigalotti, Alessia Covre, Elisabetta Fratta, Giulia Parisi, Paolo Sonego, Francesca Colizzi, Sandra Coral, Samuele Massarut, John M Kirkwood and Michele Maio

    Journal of Translational Medicine 2012 10:185

    Published on: 5 September 2012

  11. Research

    BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

    BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocyti...

    Michele Carbone, Laura Korb Ferris, Francine Baumann, Andrea Napolitano, Christopher A Lum, Erin G Flores, Giovanni Gaudino, Amy Powers, Peter Bryant-Greenwood, Thomas Krausz, Elizabeth Hyjek, Rachael Tate, Joseph Friedberg, Tracey Weigel, Harvey I Pass and Haining Yang

    Journal of Translational Medicine 2012 10:179

    Published on: 30 August 2012

  12. Research

    Integrated next-generation sequencing of 16S rDNA and metaproteomics differentiate the healthy urine microbiome from asymptomatic bacteriuria in neuropathic bladder associated with spinal cord injury

    Clinical dogma is that healthy urine is sterile and the presence of bacteria with an inflammatory response is indicative of urinary tract infection (UTI). Asymptomatic bacteriuria (ABU) represents the state in...

    Derrick E Fouts, Rembert Pieper, Sebastian Szpakowski, Hans Pohl, Susan Knoblach, Moo-Jin Suh, Shih-Ting Huang, Inger Ljungberg, Bruce M Sprague, Sarah K Lucas, Manolito Torralba, Karen E Nelson and Suzanne L Groah

    Journal of Translational Medicine 2012 10:174

    Published on: 28 August 2012

  13. Research

    Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury

    Recent studies showed that overwhelming inflammatory response mediated by the toll-like receptor (TLR)-related pathway was important in the development of acute lung injury (ALI). The aim of this study was to ...

    Zhenju Song, Chenling Yao, Jun Yin, Chaoyang Tong, Duming Zhu, Zhan Sun, Jinjun Jiang, Mian Shao, Yaping Zhang, Zhi Deng, Zhengang Tao, Si Sun and Chunxue Bai

    Journal of Translational Medicine 2012 10:166

    Published on: 17 August 2012

  14. Research

    Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response

    This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer.

    Emery Salom, Manuel Penalver, Howard Homesley, Matthew Burrell, Audrey Garrett, Cary A Presant, James Rutledge, Michael Chernick, Allan Hallquist and Mathieu Perree

    Journal of Translational Medicine 2012 10:162

    Published on: 8 August 2012

  15. Research

    Serum microRNAs as biomarkers for recurrence in melanoma

    Identification of melanoma patients at high risk for recurrence and monitoring for recurrence are critical for informed management decisions. We hypothesized that serum microRNAs (miRNAs) could provide prognos...

    Erica B Friedman, Shulian Shang, Eleazar Vega-Saenz de Miera, Jacob Ulrik Fog, Maria Wrang Teilum, Michelle W Ma, Russell S Berman, Richard L Shapiro, Anna C Pavlick, Eva Hernando, Adam Baker, Yongzhao Shao and Iman Osman

    Journal of Translational Medicine 2012 10:155

    Published on: 2 August 2012

  16. Research

    High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy

    High mobility group box 1(HMGB1) overexpression has been reported in a variety of human cancers. However, the role of HMGB1 in hepatocellular carcinoma (HCC) remains unclear. The aim of present study was to an...

    Furong Liu, Yaojun Zhang, Zhenwei Peng, Hengjun Gao, Li Xu and Minshan Chen

    Journal of Translational Medicine 2012 10:135

    Published on: 2 July 2012

  17. Review

    A systematic review and meta-analysis of 235delC mutation of GJB2 gene

    The 235delC mutation of GJB2 gene is considered as a risk factor for the non-syndromic hearing loss (NSHL), and a significant difference in the frequency and distribution of the 235delC mutation has been describe...

    Jun Yao, Yajie Lu, Qinjun Wei, Xin Cao and Guangqian Xing

    Journal of Translational Medicine 2012 10:136

    Published on: 2 July 2012

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