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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Different metabolic phenotypes may be related to nonalcoholic fatty liver disease (NAFLD), but such association whether modified by serum uric acid levels is unknown. We examined the association between differ...

    Authors: Jun Zheng, Xuerui Li, Yuan Zhang, Yuyang Miao and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:39
  2. Very low-calorie ketogenic diet (VLCKD) has shown to significantly reduce body weight and fat mass, as well as inflammation. These effects are supported by nutritional ketosis, which triggers the utilization o...

    Authors: Claudia Vetrani, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2023 21:29
  3. Nonobese metabolic dysfunction-associated fatty liver disease (MAFLD) is paradoxically associated with improved metabolic and pathological features at diagnosis but similar cardiovascular diseases (CVD) progno...

    Authors: Congxiang Shao, Lishu Xu, Pingguang Lei, Wei Wang, Shiting Feng, Junzhao Ye and Bihui Zhong
    Citation: Journal of Translational Medicine 2023 21:12
  4. Astronauts undergo significant microgravity-induced bone loss during space missions, which has become one of the three major medical problems hindering human's long-term space flight. A risk-free and antiresor...

    Authors: Ranli Gu, Hao Liu, Menglong Hu, Yuan Zhu, Xuenan Liu, Feilong Wang, Likun Wu, Danyang Song and Yunsong Liu
    Citation: Journal of Translational Medicine 2023 21:8
  5. Nonalcoholic fatty liver disease (NAFLD) is closely associated with Cardiovascular disease (CVD). We aim to examine the association of Life’s Essential 8 (LE8), the recently updated measurement of cardiovascul...

    Authors: Lili Wang, Jiayi Yi, Xinli Guo and Xiangpeng Ren
    Citation: Journal of Translational Medicine 2022 20:616
  6. Type 2 diabetes (T2D) onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. This study aims to find out the key drivers an...

    Authors: Jiachen Liu, Shenghua Liu, Zhaomei Yu, Xiaorui Qiu, Rundong Jiang and Weizheng Li
    Citation: Journal of Translational Medicine 2022 20:604

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:207

  7. Renal anemia is caused by end-stage renal disease (ESRD) but has a complex etiology. The application of dietary fiber (DF) to regulate the gut microbiota has shown effective therapeutic effects in some disease...

    Authors: Yang Li, Min Han, Jia Song, Shijin Liu, Yongjun Wang, Xinhuan Su, Kai Wei, Zhen Xu, Hui Li and Zunsong Wang
    Citation: Journal of Translational Medicine 2022 20:599
  8. Microbiota and its metabolites are known to regulate host metabolism. In cross-sectional study conducted in postmenopausal women we aimed to assess whether the microbiota, its metabolites and gut barrier integ...

    Authors: Igor Łoniewski, Monika Szulińska, Mariusz Kaczmarczyk, Konrad Podsiadło, Daniel Styburski, Karolina Skonieczna-Żydecka and Paweł Bogdański
    Citation: Journal of Translational Medicine 2022 20:585
  9. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with abnormal lipid metabolism. The present study was to identify regulatory genes related to lipid droplets (LDs) abnormal accumulation in NAFLD.

    Authors: Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan and Jiequn Li
    Citation: Journal of Translational Medicine 2022 20:529
  10. Identifying patterns of variation in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes could provide insight into the critical period when drastic changes occurred ...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Fereidoun Azizi, Davood Khalili and Majid Valizadeh
    Citation: Journal of Translational Medicine 2022 20:518
  11. Diabetic kidney disease (DKD) is among the most important causes for chronic kidney disease. Anthocyanins (ANT) are polyphenolic compounds present in various food and play an important role in ameliorating hyp...

    Authors: Yi-Xi Li, Yong-Ping Lu, Donge Tang, Bo Hu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fan, Kai-Wen Cai, Chun Tang, Yi-Qing Zhang, Ling Hong, Jing-jing Dong, Bao-zhang Guan, Liang-Hong Yin, Yong Dai, Wei-bin Bai…
    Citation: Journal of Translational Medicine 2022 20:510
  12. Apparent mineralocorticoid excess is an autosomal recessive form of monogenic disease characterized by juvenile resistant low-renin hypertension, marked hypokalemic alkalosis, low aldosterone levels, and high ...

    Authors: Yi-ting Lu, Di Zhang, Qiong-yu Zhang, Ze-ming Zhou, Kun-qi Yang, Xian-liang Zhou and Fan Peng
    Citation: Journal of Translational Medicine 2022 20:500
  13. This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model a...

    Authors: Ya Li, You Wu, Lili Wu, Lingling Qin and Tonghua Liu
    Citation: Journal of Translational Medicine 2022 20:498
  14. To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular mechanism.

    Authors: Yun Feng, Wenhua Li, Zhuoya Wang, Ruling Zhang, Yan Li, Lijuan Zang, Peiwen Wang, Zhenghong Li and Yuwei Dong
    Citation: Journal of Translational Medicine 2022 20:497
  15. Obesity (waist circumference, body mass index (BMI)) and lifestyle factors (dietary habits, smoking, alcohol drinking, Sedentary behavior) have been associated with risk of benign prostatic hyperplasia (BPH) i...

    Authors: Yong-Bo Wang, Lan Yang, Yu-Qing Deng, Si-Yu Yan, Li-Sha Luo, Ping Chen and Xian-Tao Zeng
    Citation: Journal of Translational Medicine 2022 20:495
  16. Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well...

    Authors: Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Xiang-Xu Chen, Qian Yu and Yun-Feng Rui
    Citation: Journal of Translational Medicine 2022 20:490
  17. Evidence about the relationship between triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and prediabetes (Pre-DM) in Chinese non-obese people with a normal range of low-density lipoprotein...

    Authors: Liling Wu, Xiaodan Wu, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:484
  18. Proteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney disease (CKD). However, whether all proteinuria forms are linked to renal im...

    Authors: Chun Gan, Xindi Zhou, Dan Chen, Huan Chi, Jiawen Qiu, Hui You, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang and Qiu Li
    Citation: Journal of Translational Medicine 2022 20:480
  19. The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear.

    Authors: Yu Yu, Min Gu, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Xuhua Chen, Hongxia Niu, Xiaohui Ning and Wei Hua
    Citation: Journal of Translational Medicine 2022 20:478
  20. Nutritional assessment and quality of life (QOL) have become important indices for therapeutic efficacy in patients with malignancies. We aim to develop and validate an easy-to-use questionnaire with prognosti...

    Authors: Bingdong Zhang, Yuerui Li and Yongbing Chen
    Citation: Journal of Translational Medicine 2022 20:477
  21. Trimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine (TMA), a product of gut microbiota and manufacturing industries-derived pol...

    Authors: Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Citation: Journal of Translational Medicine 2022 20:470
  22. Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbi...

    Authors: Duygu Ağagündüz, Feray Gençer Bingöl, Elif Çelik, Özge Cemali, Çiler Özenir, Fatih Özoğul and Raffaele Capasso
    Citation: Journal of Translational Medicine 2022 20:460
  23. C1q/tumor necrosis factor-related protein 1 (CTRP1) is an adipokine secreted by adipose tissue, related to chondrocyte proliferation, inflammation, and glucose homeostasis. However, the therapeutic effects on ...

    Authors: Mingzhi Ren, Jianfei Pan, Xueying Yu, Kaile Chang, Xiaopeng Yuan and Chunbo Zhang
    Citation: Journal of Translational Medicine 2022 20:449
  24. Akkermansia muciniphila (A. muciniphila) is present in the human gut microbiota from infancy and gradually increases in adulthood. The potential impact of the abundance of A. muciniphila has been studied in major...

    Authors: Arun Prasath Lakshmanan, Selvasankar Murugesan, Souhaila Al Khodor and Annalisa Terranegra
    Citation: Journal of Translational Medicine 2022 20:430
  25. Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. SGLT2 inhibitors are clinically effective in halting DKD progression. However, the underlying mechanisms remain u...

    Authors: Yong-Ping Lu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fang, Bo Hu, Chun Tang, Yi-Qing Zhang, Lianghong Yin, Dong-E. Tang, Zhi-Hua Zheng, Ting Zhu and Yong Dai
    Citation: Journal of Translational Medicine 2022 20:420
  26. The association between body mass index (BMI) and Alzheimer's disease (AD) remains controversial. Genetic and environmental factors are now considered contributors to AD risk. However, little is known about th...

    Authors: Shiqi Yuan, Wentao Wu, Wen Ma, Xiaxuan Huang, Tao Huang, MIn Peng, Anding Xu and Jun Lyu
    Citation: Journal of Translational Medicine 2022 20:417
  27. Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) in China. At present, the efficacy of BBR against HLP is relatively clear, but th...

    Authors: Yuting Chen, Kaipeng Li, Han Zhao, Zhangsen Hao, Yuxin Yang, Mingming Gao and Ding Zhao
    Citation: Journal of Translational Medicine 2022 20:412
  28. Omega-3 may alleviate the severity of coronavirus disease 2019 (COVID-19) by reducing the C-reactive protein (CRP) level, a marker for systemic inflammation. Because the scientific evidence indicating such a r...

    Authors: Amira Mohamed Taha, Ahmad Shehata Shaarawy, Mohamed Mosad Omar, Khaled Abouelmagd, Noran Magdy Shalma, Mais Alhashemi, Hala Mahmoud Ahmed, Ahmed Hafez Allam and Mohamed Abd-ElGawad
    Citation: Journal of Translational Medicine 2022 20:401
  29. An imbalance in the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of gestational diabetes mellitus (GDM) and ecl...

    Authors: Alayi Bolatai, Yujing He and Na Wu
    Citation: Journal of Translational Medicine 2022 20:400
  30. By identifying individuals at high risk for non-alcoholic fatty liver disease (NAFLD), interventional programs could be targeted more effectively. Some studies have demonstrated that triglyceride glucose-body ...

    Authors: Haofei Hu, Yong Han, Changchun Cao and Yongcheng He
    Citation: Journal of Translational Medicine 2022 20:398
  31. NorthCape4000 (NC4000) is the most participated ultra-endurance cycling race. Eight healthy male Caucasian amateur cyclists were evaluated: (a) before starting the preparation period; (b) in the week preceding...

    Authors: Maria Teresa Valenti, Michele Braggio, Arianna Minoia, Gianluigi Dorelli, Jessica Bertacco, Francesco Bertoldo, Mattia Cominacini, Tonia De Simone, Maria Grazia Romanelli, Lekhana Bhandary, Monica Mottes and Luca Dalle Carbonare
    Citation: Journal of Translational Medicine 2022 20:397
  32. The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control...

    Authors: Fengping Liu, Jiayi Sheng, Lei Hu, Bin Zhang, Wei Guo, Yang Wang, Yifeng Gu, Peng Jiang, Hao Lin, Brako Lydia, Yifan Sun, Yifan Tang, Chaoqun Gu, Shichao Wei, Qixiao Zhai, Weiguo Chen…
    Citation: Journal of Translational Medicine 2022 20:387
  33. Recently, a few studies have indicated a relationship between the gut microbiota and IgA nephropathy (IgAN). Whether the gut microbiota participates in the pathogenesis of IgAN and whether probiotics are effec...

    Authors: Jiaxing Tan, Lingqiu Dong, Zheng Jiang, Li Tan, Xinyao Luo, Gaiqin Pei, Aiya Qin, Zhengxia Zhong, Xiang Liu, Yi Tang and Wei Qin
    Citation: Journal of Translational Medicine 2022 20:382
  34. Currently, there is no approved medication for non-alcoholic fatty liver disease management. Pre-clinical and clinical studies showed that several bioactive molecules in plants or foods (i.e., curcumin complex...

    Authors: Yvelise Ferro, Roberta Pujia, Elisa Mazza, Lidia Lascala, Oscar Lodari, Samantha Maurotti, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2022 20:377
  35. Adopting healthy lifestyles and staying mentally health are two cost-effective modifiable strategies that cancer survivors can implement in self-management. We aimed to evaluate the independent, mediation, int...

    Authors: Zhao-yan Liu, Chen Wang, Yao-jun Zhang and Hui-lian Zhu
    Citation: Journal of Translational Medicine 2022 20:376
  36. The role of trimethylamine-N-oxide (TMAO) in the development of diabetes remains controversial, and prospective data are few. We aimed to investigate the association between serum TMAO and incident type 2 diab...

    Authors: Shu-yi Li, Si Chen, Xiao-ting Lu, Ai-ping Fang, Yu-ming Chen, Rong-zhu Huang, Xin-lei Lin, Zi-hui Huang, Jing-fei Ma, Bi-xia Huang and Hui-lian Zhu
    Citation: Journal of Translational Medicine 2022 20:374
  37. There is limited evidence regarding the impact of pregnancy loss on the subsequent risk of metabolic disorders. We aimed to investigate whether history of pregnancy loss is associated with the subsequent risk ...

    Authors: Maryam Rahmati, Marzieh Saei Ghare Naz, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2022 20:372
  38. Primary hyperparathyroidism (PHPT) is mainly caused by parathyroid adenoma, which produces excess parathyroid hormones. Its pathogenic mechanisms have not yet been fully understood. To investigate the mechanis...

    Authors: Wen-Xuan Zhou, Shu Wang, Ting-Chao Wu, Ling-Chao Cheng, Yao Du, Wei Wu, Chen Lin, Xin-Ying Li and Zhong-Liang Hu
    Citation: Journal of Translational Medicine 2022 20:368
  39. To compare efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoid as induction therapy in ulcerative colitis (UC).

    Authors: Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo and Yue Zeng
    Citation: Journal of Translational Medicine 2022 20:354
  40. Several studies suggest that dietary fiber intake may reduce mortality risk, but this might depend on the fiber types and the evidence regarding the role of soluble fiber or insoluble fiber on death risk remai...

    Authors: Xin Xu, Junmiao Zhang, Yanhui Zhang, Honggang Qi and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:344
  41. NAFLD and NASH are emerging as primary causes of chronic liver disease, indicating a need for an effective treatment. Mutaflor® probiotic, a microbial treatment of interest, was effective in sustaining remissi...

    Authors: Noha M. Hany, Sanaa Eissa, Manal Basyouni, Amany H. Hasanin, Yasmin M. Aboul-Ela, Nagwa M. Abo Elmagd, Iman F. Montasser, Mahmoud A. Ali, Paul J. Skipp and Marwa Matboli
    Citation: Journal of Translational Medicine 2022 20:342
  42. Vascular endothelial growth factor B (VEGFB) was regarded to improve lipid metabolism and reduce obesity-related hyperlipidemia. Whether VEGFB participates in lipid metabolism in nonalcoholic fatty liver disea...

    Authors: Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu and Yana Li
    Citation: Journal of Translational Medicine 2022 20:341
  43. Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the “male–female health-surviva...

    Authors: Qiao Zhu, Ping Ping, Pei Zhang, Chaoxue Ning, Yali Zhao, Yao Yao, Xiubing Li and Shihui Fu
    Citation: Journal of Translational Medicine 2022 20:340
  44. Hyperkalemia is a common and potentially life-threatening electrolyte disorder in maintenance hemodialysis (MHD) patients. This study aimed to evaluate the efficacy and safety of potassium-lowering regimens du...

    Authors: Lan Yao, Xiaoyang Xing, Yubao Li, Fangxing Zhang, Ping Li, Xianhui Liang and Pei Wang
    Citation: Journal of Translational Medicine 2022 20:333
  45. The oral ecosystem conditions dental health, and is known to be positively modified by oral hygiene which cannot always be performed between meals, especially outside home. It is therefore important to identif...

    Authors: Erna Cecilia Lorenzini, Barbara Lazzari, Gianluca Martino Tartaglia, Giampietro Farronato, Valentina Lanteri, Sara Botti, Filippo Biscarini, Paolo Cozzi and Alessandra Stella
    Citation: Journal of Translational Medicine 2022 20:312
  46. The development of diabetes vascular calcification (VC) is tightly associated with the inhibition of vascular smooth muscle cell (VSMC) autophagy. Previously, our team found that miR-32-5p (miR-32) promotes ma...

    Authors: Jingsong Cao, Cong Chen, Qian Chen, Yan Gao, Zhibo Zhao, Qing Yuan, Anqi Li, Shiqi Yang, Yuqi He, Xuyu Zu and Jianghua Liu
    Citation: Journal of Translational Medicine 2022 20:307
  47. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and has become a huge public health issue worldwide. Inhibition of nucleotide oligomerization domain-like receptors con...

    Authors: Chao Wu, Yanqin Bian, Bingjie Lu, Dan Wang, Nisma Lena Bahaji Azami, Gang Wei, Feng Ma and Mingyu Sun
    Citation: Journal of Translational Medicine 2022 20:294
  48. Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (S...

    Authors: Annie Bouchard-Mercier, Juan de Toro-Martín, Mélanie Nadeau, Odette Lescelleur, Stéfane Lebel, Denis Richard, Laurent Biertho, André Tchernof and Marie-Claude Vohl
    Citation: Journal of Translational Medicine 2022 20:283
  49. Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contribut...

    Authors: Hao Lin, Xiaonan Chen, Jianan Pan, Jiahan Ke, Alian Zhang, Yangyang Liu, Changqian Wang, Alex Chia Yu Chang and Jun Gu
    Citation: Journal of Translational Medicine 2022 20:278

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