Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

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  1. Research

    Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

    Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage ...

    J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche and U. Muñoz

    Journal of Translational Medicine 2015 13:326

    Published on: 14 October 2015

  2. Research

    Nutritional parameters predicting pressure ulcers and short-term mortality in patients with minimal conscious state as a result of traumatic and non-traumatic acquired brain injury

    The association between malnutrition and worse outcomes as pressure ulcers and mortality is well established in a variety of setting. Currently none investigation was conducted in patients with long-term conse...

    Tiziana Montalcini, Marta Moraca, Yvelise Ferro, Stefano Romeo, Sebastiano Serra, Maria Girolama Raso, Francesco Rossi, Walter G. Sannita, Giuliano Dolce and Arturo Pujia

    Journal of Translational Medicine 2015 13:305

    Published on: 17 September 2015

  3. Research

    Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire

    Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association be...

    Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao and Silvia Savastano

    Journal of Translational Medicine 2015 13:303

    Published on: 16 September 2015

  4. Research

    The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

    Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interac...

    Maria L. Mansego, Griselda De Marco, Carmen Ivorra, Raúl Lopez-Izquierdo, Sonsoles Morcillo, Gemma Rojo-Martínez, Verónica González-Albert, Fernando Martinez, Federico Soriguer, Juan C. Martín-Escudero, Josep Redon and F. Javier Chaves

    Journal of Translational Medicine 2015 13:286

    Published on: 2 September 2015

  5. Research

    The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism

    Ipomoea aquatica (Convolvulaceae) and Enhydra fluctuans (Asteraceae), two aquatic vegetables, are traditionally used against heavy metal toxicity in traditional medicines in India. The...

    Tarun K Dua, Saikat Dewanjee, Ritu Khanra, Niloy Bhattacharya, Bhuvan Bhaskar, Muhammad Zia-Ul-Haq and Vincenzo De Feo

    Journal of Translational Medicine 2015 13:245

    Published on: 28 July 2015

  6. Review

    Taurine: the appeal of a safe amino acid for skeletal muscle disorders

    Taurine is a natural amino acid present as free form in many mammalian tissues and in particular in skeletal muscle. Taurine exerts many physiological functions, including membrane stabilization, osmoregulatio...

    Annamaria De Luca, Sabata Pierno and Diana Conte Camerino

    Journal of Translational Medicine 2015 13:243

    Published on: 25 July 2015

  7. Research

    Dietary flavonoid intake and cardiovascular risk: a population-based cohort study

    The cardio-protective effects of flavonoids are still controversial; many studies referred to the benefits of specific foods, such as soy, cocoa, tea. A population-based cohort of middle-aged adults, coming fr...

    Valentina Ponzo, Ilaria Goitre, Maurizio Fadda, Roberto Gambino, Antonella De Francesco, Laura Soldati, Luigi Gentile, Paola Magistroni, Maurizio Cassader and Simona Bo

    Journal of Translational Medicine 2015 13:218

    Published on: 8 July 2015

  8. Research

    Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice

    Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role of anthocyanins in diabetic nephropathy is poorly un...

    Eun Sil Koh, Ji Hee Lim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Bum Soon Choi, Hye Won Kim, Seong Yeon Hwang, Sae Woong Kim, Cheol Whee Park and Yoon Sik Chang

    Journal of Translational Medicine 2015 13:203

    Published on: 27 June 2015

  9. Research

    Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

    Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple ‘hits’ have been reported to contribute to NAFLD progression to non-alcoholic steatohepatitis (NASH), fibrosis and liver cancer,...

    Michal Ganz, Terence N Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys and Gyongyi Szabo

    Journal of Translational Medicine 2015 13:193

    Published on: 16 June 2015

  10. Review

    Impact of heparanase on renal fibrosis

    Tubulo-interstitial fibrosis has been recognized as the hallmark of progression of chronic kidney disease, but, despite intensive research studies, there are currently no biomarkers or effective treatments for...

    Valentina Masola, Gianluigi Zaza, Maurizio Onisto, Antonio Lupo and Giovanni Gambaro

    Journal of Translational Medicine 2015 13:181

    Published on: 4 June 2015

  11. Research

    Bisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: a cross-sectional study on adult male population

    The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic altera...

    Silvia Savastano, Giovanni Tarantino, Vittoria D’Esposito, Federica Passaretti, Serena Cabaro, Antonietta Liotti, Domenico Liguoro, Giuseppe Perruolo, Fabiana Ariemma, Carmine Finelli, Francesco Beguinot, Pietro Formisano and Rossella Valentino

    Journal of Translational Medicine 2015 13:169

    Published on: 29 May 2015

  12. Research

    Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca2+ cycling proteins

    Cardiac hypertrophy is a compensatory stage of the heart in response to stress such as pressure overload (PO), which can develop into heart failure (HF) if left untreated. Resveratrol has been reported to prev...

    Qi Dong, Zhiye Wu, Xiaoyun Li, Jianyun Yan, Luning Zhao, Chuntao Yang, Junjiang Lu, Ju Deng and Minsheng Chen

    Journal of Translational Medicine 2014 12:323

    Published on: 26 November 2014

  13. Research

    A randomised translational trial of lifestyle intervention using a 3-tier shared care approach on pregnancy outcomes in Chinese women with gestational diabetes mellitus but without diabetes

    There are no randomised controlled trials to demonstrate whether lifestyle modifications can improve pregnancy outcomes of gestational diabetes mellitus (GDM) diagnosed by the International Association of Diab...

    Xilin Yang, Huiguang Tian, Fuxia Zhang, Cuiping Zhang, Yi Li, Junhong Leng, Leishen Wang, Gongsu Liu, Ling Dong, Zhijie Yu, Gang Hu and Juliana CN Chan

    Journal of Translational Medicine 2014 12:290

    Published on: 28 October 2014

    The Erratum to this article has been published in Journal of Translational Medicine 2015 13:70

  14. Research

    A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones

    Breast cancer risk is partially determined by several hormone-related factors. Preclinical and clinical studies suggested that resveratrol may modulate these hormonal factors.

    H-H Sherry Chow, Linda L Garland, Brandy M Heckman-Stoddard, Chiu-Hsieh Hsu, Valerie D Butler, Catherine A Cordova, Wade M Chew and Terri L Cornelison

    Journal of Translational Medicine 2014 12:223

    Published on: 14 August 2014

  15. Research

    University courses, eating problems and muscle dysmorphia: are there any associations?

    Orthorexia and muscle dysmorphia are disorders affecting above all young adults whose prevalence and social impact are still unclear. We aimed to evaluate the prevalence of the traits of orthorexia and muscle ...

    Simona Bo, Rossana Zoccali, Valentina Ponzo, Laura Soldati, Luca De Carli, Andrea Benso, Elisabetta Fea, Alberto Rainoldi, Marilena Durazzo, Secondo Fassino and Giovanni Abbate-Daga

    Journal of Translational Medicine 2014 12:221

    Published on: 7 August 2014

  16. Review

    Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

    The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol,...

    Stefania Bulotta, Marilena Celano, Saverio Massimo Lepore, Tiziana Montalcini, Arturo Pujia and Diego Russo

    Journal of Translational Medicine 2014 12:219

    Published on: 3 August 2014

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