Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. Research

    Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones

    Early events in HIV infection are still poorly understood; virus derived from acute infections, the transmitted/founders IMCs, could provide more reliable information as they represent strains that established...

    Riccardo Miglietta, Claudia Pastori, Assunta Venuti, Christina Ochsenbauer and Lucia Lopalco

    Journal of Translational Medicine 2014 12:346

    Published on: 13 December 2014

  2. Research

    Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms

    Understanding the mechanisms by which some individuals are able to naturally control HIV-1 infection is an important goal of AIDS research. We here describe the case of an HIV-1+ woman, CASE1, who has spontaneous...

    Marco Moroni, Silvia Ghezzi, Paolo Baroli, Silvia Heltai, Davide De Battista, Simone Pensieroso, Mariangela Cavarelli, Stefania Dispinseri, Irene Vanni, Claudia Pastori, Pietro Zerbi, Antonella Tosoni, Elisa Vicenzi, Manuela Nebuloni, Kim Wong, Hong Zhao…

    Journal of Translational Medicine 2014 12:335

    Published on: 5 December 2014

  3. Research

    Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

    MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC...

    Yi Zhu, Jing-Jing Zhang, Kun-Ling Xie, Jie Tang, Wen-Biao Liang, Rong Zhu, Yan Zhu, Bin Wang, Jin-Qiu Tao, Xiao-Fei Zhi, Zheng Li, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao and Ze-Kuan Xu

    Journal of Translational Medicine 2014 12:309

    Published on: 4 November 2014

  4. Research

    TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix

    Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA ...

    Maria Lina Tornesello, Clorinda Annunziata, Luigi Buonaguro, Simona Losito, Stefano Greggi and Franco M Buonaguro

    Journal of Translational Medicine 2014 12:255

    Published on: 16 September 2014

  5. Research

    Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients

    IL-10+ regulatory B (Bregs), CD4+Foxp3+ regulatory T (Tregs), and CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells regulate the progression of infection disease. This study aimed at examining how those cells ...

    Li Wang, Jinpeng Qiu, Lei Yu, Xiaoli Hu, Pingwei Zhao and Yanfang Jiang

    Journal of Translational Medicine 2014 12:251

    Published on: 9 September 2014

  6. Research

    In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

    Treatment with interferon-alpha (IFN-α) and ribavirin successfully clears hepatitis C virus (HCV) infection in 50% of patients infected with genotype 1. Addition of NS3-4A protease inhibitors (PIs) increases r...

    Nollaig M Bourke, Mary-Teresa O’Neill, Shahzad Sarwar, Suzanne Norris, Stephen Stewart, John E Hegarty, Nigel J Stevenson and Cliona O’Farrelly

    Journal of Translational Medicine 2014 12:206

    Published on: 21 July 2014

  7. Research

    HBsAg as an important predictor of HBeAg seroconversion following antiviral treatment for HBeAg-positive chronic hepatitis B patients

    Serum quantitative hepatitis B surface antigen (HBsAg) levels may be an important predictor of hepatitis B e antigen (HBeAg) seroconversion (SC) in HBeAg-positive chronic hepatitis B (CHB) patients during anti...

    Jiezuan Yang, Jiajia Chen, Ping Ye, Linfeng Jin, Wei Wu, Guoping Sheng and Lan-Juan Li

    Journal of Translational Medicine 2014 12:183

    Published on: 25 June 2014

  8. Research

    Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-κB inhibition

    Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to a family of endogenous signaling mediators termed “gasotransmitters”. Recent studies suggest that H2S modulates many ce...

    Francesca Benedetti, Sergio Davinelli, Selvi Krishnan, Robert C Gallo, Giovanni Scapagnini, Davide Zella and Sabrina Curreli

    Journal of Translational Medicine 2014 12:145

    Published on: 24 May 2014

  9. Review

    Tickling the TLR7 to cure viral hepatitis

    Chronic hepatitis B and C are the leading causes of liver disease and liver transplantation worldwide. Ability to mount an effective immune response against both HBV and HCV is associated with spontaneous clea...

    Emily Funk, Shyam Kottilil, Bruce Gilliam and Rohit Talwani

    Journal of Translational Medicine 2014 12:129

    Published on: 14 May 2014

  10. Research

    Comprehensive proteomic analysis of white blood cells from chikungunya fever patients of different severities

    Chikungunya fever (CHIKF) is a recently re-emerged mosquito transmitted viral disease caused by the chikungunya virus (CHIKV), an Alphavirus belonging to the family Togaviridae. Infection of humans with CHIKV can...

    Nitwara Wikan, Sarawut Khongwichit, Weerawat Phuklia, Sukathida Ubol, Tipparat Thonsakulprasert, Montri Thannagith, Duangrudee Tanramluk, Atchara Paemanee, Suthathip Kittisenachai, Sittiruk Roytrakul and Duncan R Smith

    Journal of Translational Medicine 2014 12:96

    Published on: 11 April 2014

  11. Research

    Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort

    Human papillomavirus (HPV) infection has traditionally been regarded as a sexually transmitted disease (STD), but recent evidence implicates that an infected mother can transmit HPV to her newborn during pregn...

    Hanna-Mari Koskimaa, Anna E Paaso, Marij JP Welters, Seija E Grénman, Kari J Syrjänen, Sjoerd H van der Burg and Stina M Syrjänen

    Journal of Translational Medicine 2014 12:44

    Published on: 13 February 2014

  12. Research

    Prediction of individual immune responsiveness to a candidate vaccine by a systems vaccinology approach

    We have previously shown that a candidate idiotype vaccine, based on the IGKV3-20 light chain protein, is able to induce activation of circulating antigen presenting cells (APCs) in both HCV-positive and HCV-n...

    Annacarmen Petrizzo, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro and Luigi Buonaguro

    Journal of Translational Medicine 2014 12:11

    Published on: 15 January 2014

  13. Research

    Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer

    Digestive malignancies, especially pancreatic cancer (PC), gastric cancer (GC), and colorectal cancer (CRC), still occur at persistently high rates, and disease progression in these cancers has been associated...

    Yun-Peng Peng, Yi Zhu, Jing-Jing Zhang, Ze-Kuan Xu, Zhu-Yin Qian, Cun-Cai Dai, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qiang Li, Qing Du and Yi Miao

    Journal of Translational Medicine 2013 11:262

    Published on: 20 October 2013

  14. Research

    The status of HBV infection influences metastatic pattern and survival in Chinese patients with pancreatic cancer

    It has been proved that hepatitis B virus (HBV) infection alters the metastatic pattern and affects survival in colorectal cancer (CRC) and hepatocellular carcinoma (HCC), while the influence of HBV infection ...

    Xiao-li Wei, Miao-zhen Qiu, Wei-wei Chen, Ying Jin, Chao Ren, Feng Wang, Hui-yan Luo, Zhi-qiang Wang, Dong-sheng Zhang, Feng-hua Wang, Yu-hong Li and Rui-hua Xu

    Journal of Translational Medicine 2013 11:249

    Published on: 8 October 2013

  15. Research

    Forkhead box transcription factor 1 expression in gastric cancer: FOXM1 is a poor prognostic factor and mediates resistance to docetaxel

    Forkhead box transcription factor 1 (FOXM1) has been reported to overexpress and correlate with pathogenesis in a variety of human malignancies. However, little research has been done to investigate its clinic...

    Xiaoxiao Li, Wensheng Qiu, Bin Liu, Ruyong Yao, Shihai Liu, Yasai Yao and Jun Liang

    Journal of Translational Medicine 2013 11:204

    Published on: 3 September 2013

  16. Research

    Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate

    Trimeric soluble forms of HIV gp140 envelope glycoproteins represent one of the closest molecular structures compared to native spikes present on intact virus particles. Trimeric soluble gp140 have been genera...

    Maria Luisa Visciano, Maria Tagliamonte, Guillaume Stewart-Jones, Leo Heyndrickx, Guido Vanham, Marianne Jansson, Anders Fomsgaard, Berit Grevstad, Meghna Ramaswamy, Franco M Buonaguro, Maria Lina Tornesello, Priscilla Biswas, Gabriella Scarlatti and Luigi Buonaguro

    Journal of Translational Medicine 2013 11:165

    Published on: 8 July 2013

  17. Research

    L1R, A27L, A33R and B5R vaccinia virus genes expressed by fowlpox recombinants as putative novel orthopoxvirus vaccines

    The traditional smallpox vaccine, administered by scarification, was discontinued in the general population from 1980, because of the absence of new smallpox cases. However, the development of an effective pro...

    Sole Maria Pacchioni, Massimiliano Bissa, Carlo Zanotto, Carlo De Giuli Morghen, Elena Illiano and Antonia Radaelli

    Journal of Translational Medicine 2013 11:95

    Published on: 11 April 2013

  18. Research

    HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

    Human papilloma virus type 16 (HPV16)-induced gynecological cancers, in particular cervical cancers, are found in many women worldwide. The HPV16 encoded oncoproteins E6 and E7 are tumor-specific targets for t...

    Mariette I E van Poelgeest, Marij J P Welters, Edith M G van Esch, Linda F M Stynenbosch, Gijs Kerpershoek, Els L van Persijn van Meerten, Muriel van den Hende, Margriet J G Löwik, Dorien M A Berends-van der Meer, Lorraine M Fathers, A Rob P M Valentijn, Jaap Oostendorp, Gert Jan Fleuren, Cornelis J M Melief, Gemma G Kenter and Sjoerd H van der Burg

    Journal of Translational Medicine 2013 11:88

    Published on: 4 April 2013

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