Cell, tissue and gene therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

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  1. Research

    Automation of cellular therapy product manufacturing: results of a split validation comparing CD34 selection of peripheral blood stem cell apheresis product with a semi-manual vs. an automatic procedure

    Automation of cell therapy manufacturing promises higher productivity of cell factories, more economical use of highly-trained (and costly) manufacturing staff, facilitation of processes requiring manufacturin...

    Christiane Hümmer, Carolin Poppe, Milica Bunos, Belinda Stock, Eva Wingenfeld, Volker Huppert, Juliane Stuth, Kristina Reck, Mike Essl, Erhard Seifried and Halvard Bonig

    Journal of Translational Medicine 2016 14:76

    Published on: 16 March 2016

  2. Research

    Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in promoting repair of bone defects

    High levels of pro-inflammatory cytokines in leukocyte- and platelet-rich plasma (L-PRP) may activate the nuclear factor κB (NF-κB) pathway to counter the beneficial effect of the growth factors on bone regene...

    Wenjing Yin, Xin Qi, Yuelei Zhang, Jiagen Sheng, Zhengliang Xu, Shicong Tao, Xuetao Xie, Xiaolin Li and Changqing Zhang

    Journal of Translational Medicine 2016 14:73

    Published on: 15 March 2016

  3. Research

    Gene expression identifies heterogeneity of metastatic behavior among gastrointestinal stromal tumors

    Adjuvant imatinib is useful in patients with gastrointestinal stromal tumors (GIST) at high risk of recurrence. At present, the risk of recurrence is determined based on tumor size, mitotic rate, tumor site, a...

    Keith M. Skubitz, Kate Geschwind, Wayne W. Xu, Joseph S. Koopmeiners and Amy P. N. Skubitz

    Journal of Translational Medicine 2016 14:51

    Published on: 13 February 2016

  4. Research

    Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively

    Orthotopic liver transplantation is the only effective treatment for liver failure but limited with shortage of available donor organs. Recent studies show promising results of mesenchymal stem cells (MSCs)-ba...

    Biao Huang, Xixi Cheng, Huafeng Wang, Wenjing Huang, Zha la Ga hu, Dan Wang, Kai Zhang, Huan Zhang, Zhenyi Xue, Yurong Da, Ning Zhang, Yongcheng Hu, Zhi Yao, Liang Qiao, Fei Gao and Rongxin Zhang

    Journal of Translational Medicine 2016 14:45

    Published on: 9 February 2016

  5. Research

    Human endometrial regenerative cells attenuate renal ischemia reperfusion injury in mice

    Endometrial regenerative cells (ERCs) is an attractive novel type of adult mesenchymal stem cells that can be non-invasively obtained from menstrual blood and are easily replicated at a large scale without tum...

    Peng Sun, Jian Liu, Wenwen Li, Xiaoxi Xu, Xiangying Gu, HongYue Li, Hongqiu Han, Caigan Du and Hao Wang

    Journal of Translational Medicine 2016 14:28

    Published on: 28 January 2016

  6. Research

    Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells

    Craniomaxillofacial defects secondary to trauma, tumor resection, or congenital malformations are frequent unmet challenges, due to suboptimal alloplastic options and limited autologous tissues such as bone. S...

    Amy L. Strong, Ryan S. Hunter, Robert B. Jones, Annie C. Bowles, Maria F. Dutreil, Dina Gaupp, Daniel J. Hayes, Jeffrey M. Gimble, Benjamin Levi, Margaret A. McNulty and Bruce A. Bunnell

    Journal of Translational Medicine 2016 14:27

    Published on: 27 January 2016

  7. Research

    A therapeutic cancer vaccine against GL261 murine glioma

    Glioblastoma (GBM) is the deadliest of brain tumors. Standard treatment for GBM is surgery, followed by combined radiation therapy and chemotherapy. Current therapy prolongs survival but does not offer a cure....

    Mark S. Kindy, Jin Yu, Hong Zhu, Michael T. Smith and Sebastiano Gattoni-Celli

    Journal of Translational Medicine 2016 14:1

    Published on: 5 January 2016

  8. Research

    Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate

    Pooled human platelet lysate (pHPL) is an efficient alternative to xenogenic supplements for ex vivo expansion of mesenchymal stem cells (MSCs) in clinical studies. Currently, porcine heparin is used in pHPL-s...

    Sandra Laner-Plamberger, Thomas Lener, Doris Schmid, Doris A. Streif, Tina Salzer, Michaela Öller, Cornelia Hauser-Kronberger, Thorsten Fischer, Volker R. Jacobs, Katharina Schallmoser, Mario Gimona and Eva Rohde

    Journal of Translational Medicine 2015 13:354

    Published on: 10 November 2015

  9. Protocol

    Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study

    Mesenchymal stromal cells (MSC) may serve as an attractive therapy in renal transplantation due to their immunosuppressive and reparative properties. While most studies have used autologous MSCs, allogeneic MS...

    Marlies E. J. Reinders, Geertje J. Dreyer, Jonna R. Bank, Helene Roelofs, Sebastiaan Heidt, Dave L. Roelen, Maarten L. Zandvliet, Volkert A. L. Huurman, Wim E. Fibbe, Cees van Kooten, Frans H. J. Claas, Ton J. Rabelink and Johan W. de Fijter

    Journal of Translational Medicine 2015 13:344

    Published on: 4 November 2015

  10. Research

    Autologous immuno magnetically selected CD133+ stem cells in the treatment of no-option critical limb ischemia: clinical and contrast enhanced ultrasound assessed results in eight patients

    Demonstrate the safety and effectiveness of highly purified CD133+ autologous stem cells in critical limb ischemia (CLI).

    Vittorio Arici, Cesare Perotti, Calliada Fabrizio, Claudia Del Fante, Franco Ragni, Francesco Alessandrino, Gianluca Viarengo, Michele Pagani, Alessia Moia, Carmine Tinelli and Antonio Bozzani

    Journal of Translational Medicine 2015 13:342

    Published on: 3 November 2015

  11. Review

    Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique?

    Angiogenesis is essential for the growth and metastasis of solid tumors. The tumor endothelium exists in a state of chronic activation and proliferation, fueled by the tumor milieu where angiogenic mediators a...

    Samuel C. Wagner, Thomas E. Ichim, Hong Ma, Julia Szymanski, Jesus A. Perez, Javier Lopez, Vladimir Bogin, Amit N. Patel, Francisco M. Marincola and Santosh Kesari

    Journal of Translational Medicine 2015 13:340

    Published on: 29 October 2015

  12. Research

    In vitro migration and proliferation (“wound healing”) potential of mesenchymal stromal cells generated from human CD271+ bone marrow mononuclear cells

    Emerging evidence indicates that mesenchymal stromal cells (MSCs) isolated from different tissue sources may be used in vivo as tissue restorative agents. To date, there is no evidence, however, on migration a...

    Hatixhe Latifi-Pupovci, Zyrafete Kuçi, Sibylle Wehner, Halvard Bönig, Ralf Lieberz, Thomas Klingebiel, Peter Bader and Selim Kuçi

    Journal of Translational Medicine 2015 13:315

    Published on: 25 September 2015

  13. Research

    LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

    Within the last few years, it has become evident that LPS-preconditioned mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including increased trophic support and improved regenerative ...

    Dongdong Ti, Haojie Hao, Chuan Tong, Jiejie Liu, Liang Dong, Jingxi Zheng, Yali Zhao, Huiling Liu, Xiaobing Fu and Weidong Han

    Journal of Translational Medicine 2015 13:308

    Published on: 19 September 2015

  14. Research

    Identification of apoptosis-related microRNAs and their target genes in myocardial infarction post-transplantation with skeletal myoblasts

    Skeletal myoblasts (SkMs) has provided a promising treatment for myocardial infarction (MI). Functioning as posttranscriptional regulators, microRNAs (miRNAs) play important roles in cardiac repairment and s...

    Qi Liu, Guo Qing Du, Zhi Tao Zhu, ChunYang Zhang, Xiao Wei Sun, Jing Jin Liu, Xia Li, Yong Shun Wang and Wen Juan Du

    Journal of Translational Medicine 2015 13:270

    Published on: 19 August 2015

  15. Research

    A novel placental like alkaline phosphate promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting

    Placental like alkaline phosphate (PLAP), an oncofetal antigen, is highly expressed in germ cell, cervical, ovarian and several other tumour types but minimally in normal tissues. The expression of a PLAP prom...

    Imran Khan, Mohammad Khalid Zakaria, Mukesh Kumar, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha

    Journal of Translational Medicine 2015 13:254

    Published on: 5 August 2015

    The Erratum to this article has been published in Journal of Translational Medicine 2015 13:300

  16. Research

    Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

    Reactivation of latent viruses such as human cytomegalovirus (HCMV) after allogeneic hematopoietic stem cell transplantation (HSCT) results in high morbidity and mortality. Effective immunization against HCMV ...

    Bala Sai Sundarasetty, Stephan Kloess, Olaf Oberschmidt, Sonja Naundorf, Klaus Kuehlcke, Anusara Daenthanasanmak, Laura Gerasch, Constanca Figueiredo, Rainer Blasczyk, Eliana Ruggiero, Raffaele Fronza, Manfred Schmidt, Christof von Kalle, Michael Rothe, Arnold Ganser, Ulrike Koehl…

    Journal of Translational Medicine 2015 13:240

    Published on: 22 July 2015

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