Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Research

    Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy

    Hemodynamic load leads to cardiac hypertrophy and heart failure. While afterload (pressure overload) induces concentric hypertrophy, elevation of preload (volume overload) yields eccentric hypertrophy and is a...

    Belal A. Mohamed, Abdul R. Asif, Moritz Schnelle, Mohamed Qasim, Sara Khadjeh, Dawid Lbik, Peter Schott, Gerd Hasenfuss and Karl Toischer

    Journal of Translational Medicine 2016 14:149

    Published on: 27 May 2016

  2. Methodology

    Integrated whole-heart computational workflow for inverse potential mapping and personalized simulations

    Integration of whole-heart activation simulations and inverse potential mapping (IPM) could benefit the guidance and planning of electrophysiological procedures. Routine clinical application requires a fast an...

    P. Bhagirath, A. W. M. van der Graaf, J. de Hooge, N. M. S. de Groot and M. J. W. Götte

    Journal of Translational Medicine 2016 14:147

    Published on: 25 May 2016

  3. Research

    Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia–reperfusion injury

    To investigate whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion (I/R) heart and promotes CSC mobilization and ...

    Guo-hua Li, Bin Luo, Yan-xia Lv, Fei Zheng, Lu Wang, Meng-xi Wei, Xian-yu Li, Lei Zhang, Jia-ning Wang, Shi-you Chen, Jun-Ming Tang and Xiaohua He

    Journal of Translational Medicine 2016 14:116

    Published on: 4 May 2016

  4. Research

    Next-generation sequencing for diagnosis of thoracic aortic aneurysms and dissections: diagnostic yield, novel mutations and genotype phenotype correlations

    Thoracic aortic aneurysms and dissections (TAAD) are silent but possibly lethal condition with up to 40 % of cases being hereditary. Genetic background is heterogeneous. Recently next-generation sequencing ena...

    J. K. Poninska, Z. T. Bilinska, M. Franaszczyk, E. Michalak, M. Rydzanicz, E. Szpakowski, A. Pollak, B. Milanowska, G. Truszkowska, P. Chmielewski, A. Sioma, H. Janaszek-Sitkowska, A. Klisiewicz, I. Michalowska, M. Makowiecka-Ciesla, P. Kolsut…

    Journal of Translational Medicine 2016 14:115

    Published on: 4 May 2016

  5. Research

    Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study

    The prevalence of hyperuricemia has increased dramatically during the past several decades. Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other kn...

    Fengjiang Wei, Ning Sun, Chunyou Cai, Shuzhi Feng, Jianli Tian, Wentao Shi, Weili Xu, Yaogang Wang, Xilin Yang and Wei-Dong Li

    Journal of Translational Medicine 2016 14:110

    Published on: 30 April 2016

  6. Research

    miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction

    Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with re...

    Margherita Gigante, Paola Pontrelli, Wolfgang Herr, Maddalena Gigante, Morena D’Avenia, Gianluigi Zaza, Elisabetta Cavalcanti, Matteo Accetturo, Giuseppe Lucarelli, Giuseppe Carrieri, Michele Battaglia, Walter J. Storkus, Loreto Gesualdo and Elena Ranieri

    Journal of Translational Medicine 2016 14:84

    Published on: 11 April 2016

  7. Research

    Resolvin D1 mitigates energy metabolism disorder after ischemia–reperfusion of the rat lung

    Energy metabolism disorder is a critical process in lung ischemia–reperfusion injury (LIRI). This study was aimed to determine the effects of resolvin D1 (RvD1) on the energy metabolism in LIRI.

    Qifeng Zhao, Ji Wu, Qingwang Hua, Zhiyong Lin, Leping Ye, Weixi Zhang, Guowei Wu, Jie Du, Jie Xia, Maoping Chu and Xingti Hu

    Journal of Translational Medicine 2016 14:81

    Published on: 24 March 2016

  8. Research

    The lack of aspirin resistance in patients with coronary artery disease

    Aspirin resistance established by different laboratory methods is still a debated problem. Using COX1 specific methods no aspirin resistance was detected among healthy volunteers. Here we tested the effect of ...

    Nóra Homoródi, Emese G. Kovács, Sarolta Leé, Éva Katona, Amir H. Shemirani, Gizella Haramura, László Balogh, Zsuzsanna Bereczky, Gabriella Szőke, Hajna Péterfy, Róbert G. Kiss, István Édes and László Muszbek

    Journal of Translational Medicine 2016 14:74

    Published on: 15 March 2016

  9. Research

    Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease

    Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features of peripheral artery disease (PAD). The myopathy of PAD is characterized by myofiber degeneration in association with extracellula...

    Duy M. Ha, Lauren C. Carpenter, Panagiotis Koutakis, Stanley A. Swanson, Zhen Zhu, Mina Hanna, Holly K. DeSpiegelaere, Iraklis I. Pipinos and George P. Casale

    Journal of Translational Medicine 2016 14:39

    Published on: 4 February 2016

  10. Research

    Upregulation of miR-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF

    Endothelial progenitor cells (EPCs) contribute to recanalization of deep vein thrombosis (DVT). This study aimed to detect miRNA expression profiles in EPCs from patients with DVT and characterize the role of ...

    Lingshang Kong, Nan Hu, Xiaolong Du, Wenbin Wang, Hong Chen, Wendong Li, Sen Wei, Hao Zhuang, Xiaoqiang Li and Chenglong Li

    Journal of Translational Medicine 2016 14:23

    Published on: 22 January 2016

  11. Research

    Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction

    Heart failure with ejection fraction (HFpEF) is a syndrome resulting from several co-morbidities in which specific mediators are unknown. The platelet proteome responds to disease processes. We hypothesize tha...

    Roseanne Raphael, Diana Purushotham, Courtney Gastonguay, Marla A. Chesnik, Wai-Meng Kwok, Hsiang-En Wu, Sanjiv J. Shah, Shama P. Mirza and Jennifer L. Strande

    Journal of Translational Medicine 2016 14:18

    Published on: 20 January 2016

  12. Research

    Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models

    Psoriasis patients exhibit an increased risk of atherothrombotic events, including myocardial infarction and stroke. Clinical evidence suggests that psoriasis patients with early onset and more severe disease ...

    Jackelyn B. Golden, Yunmei Wang, Yi Fritz, Doina Diaconu, Xiufen Zhang, Sara M. Debanne, Daniel I. Simon, Thomas S. McCormick and Nicole L. Ward

    Journal of Translational Medicine 2015 13:382

    Published on: 16 December 2015

  13. Research

    MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo

    XBP1 is a key transcription factor of the unfolded protein response in mammalian cells, which is involved in several cardiovascular pathological progression including cardiac hypertrophy and myocardial infarct...

    Quanlu Duan, Chen Chen, Lei Yang, Ni Li, Wei Gong, Sheng Li and Dao Wen Wang

    Journal of Translational Medicine 2015 13:363

    Published on: 16 November 2015

  14. Research

    Monocytes/macrophages activation contributes to b-gamma-glutamyltransferase accumulation inside atherosclerotic plaques

    Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT ...

    Eugenia Belcastro, Maria Franzini, Silvana Cianchetti, Evelina Lorenzini, Silvia Masotti, Vanna Fierabracci, Angela Pucci, Alfonso Pompella and Alessandro Corti

    Journal of Translational Medicine 2015 13:325

    Published on: 13 October 2015

  15. Research

    Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells

    Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of hypertensive nephropathy (HN). Cytoskeletal remodelling is necessary for the activation of NF-κB. An actin-bindin...

    Quan-zhen Wang, Hai-qing Gao, Ying Liang, Jun Zhang, Jian Wang and Jie Qiu

    Journal of Translational Medicine 2015 13:323

    Published on: 8 October 2015

  16. Research

    PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice

    Methionine sulfoxide reductase A (MsrA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, therapeutic use of exogenous MsrA in ox...

    Yao Wu, Guanghui Xie, Yanyong Xu, Li Ma, Chuanfeng Tong, Daping Fan, Fen Du and Hong Yu

    Journal of Translational Medicine 2015 13:316

    Published on: 26 September 2015

  17. Research

    Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy

    Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertroph...

    Lu Fang, Andris H. Ellims, Xiao-lei Moore, David A. White, Andrew J. Taylor, Jaye Chin-Dusting and Anthony M. Dart

    Journal of Translational Medicine 2015 13:314

    Published on: 24 September 2015

  18. Research

    A scaling aneurysm model-based approach to assessing the role of flow pattern and energy loss in aneurysm rupture prediction

    Energy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to...

    Yunling Long, Jingru Zhong, Hongyu Yu, Huagang Yan, Zhizheng Zhuo, Qianqian Meng, Xinjian Yang and Haiyun Li

    Journal of Translational Medicine 2015 13:311

    Published on: 22 September 2015

  19. Research

    Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals

    From a pharmacological perspective, readily-available, well-characterized animal models of cardiovascular disease, including relevant in vivo markers of atherosclerosis are important for evaluation of novel dr...

    Trine Pagh Ludvigsen, Rikke Kaae Kirk, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Torben Martinussen, Jonas Kildegaard, Peter M. H. Heegaard, Jens Lykkesfeldt and Lisbeth Høier Olsen

    Journal of Translational Medicine 2015 13:312

    Published on: 22 September 2015

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